منابع مشابه
Gelsemium sempervirens and Animal Behavioral Models
In traditional Materia Medica, Gelsemium sempervirens (G. sempervirens) is described as a remedy for a variety of anxiety-like psychological and behavioral symptoms, however consistent evidence of its efficacy is lacking. In our recent experimental studies (Bellavite et al., 2009; Magnani et al., 2010), groups of CD1 mice were treated with highly diluted solutions of G. sempervirens, or with co...
متن کاملPharmacological Evaluation of Gelsemium sempervirens roots for CNS Depressant Activity
The aim of the present study was to investigate CNS depressant activity of methanolic extract of Gelsemium sempervirens roots. G. sempervirens Ait (Loganiaceae) is used traditionally in the treatment of migraine, neuralgia, rheumatism, restlessness, mental irritability, insomnia and ovarian and uterine pain. The plant was found to contain alkaloids gelsemine, gelseminine, gelsemoidine and gelse...
متن کاملExperimental neuropharmacology of Gelsemium sempervirens: Recent advances and debated issues
Gelsemium sempervirens L. (Gelsemium) is traditionally used for its anxiolytic-like properties and its action mechanism in laboratory models are under scrutiny. Evidence from rodent models was reported suggesting the existence of a high sensitivity of central nervous system to anxiolytic power of Gelsemium extracts and Homeopathic dilutions. In vitro investigation of extremely low doses of this...
متن کاملHomeopathic Doses of Gelsemium sempervirens Improve the Behavior of Mice in Response to Novel Environments
Gelsemium sempervirens is used in homeopathy for treating patients with anxiety related symptoms, however there have been few experimental studies evaluating its pharmacological activity. We have investigated the effects of homeopathic doses of G. sempervirens on mice, using validated behavioral models. Centesimal (CH) dilutions/dynamizations of G. sempervirens, the reference drug diazepam (1 m...
متن کاملGelsemine and Gelsemium sempervirens L. Extracts in Animal Behavioral Test: Comments and Related Biases
due to Gelsemium noxious compounds if more selective compounds can be identified. Centesimal (C) dilutions of G. sempervirens (4C, 5C, 7C, 9C, and 30C) appeared able to change significantly mouse behavioral effects as assessed in the open-field (OF) and light–dark (LD) tests in blind and randomized fashion (Magnani et al., 2010) but effects in the elevated plus-maze, an assay considered to be i...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1888
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm188809131191102